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Recombinant human 14-3-3 sigma protein

ArtNr NKM-ATGP0435-100ug
Hersteller NKMAX
Menge 100 ug
Quantity options 100 ug 20 ug 500 ug
Kategorie
Typ Proteins Recombinant
Format Liquid
Applikationen SDS-PAGE
Specific against Human (Homo sapiens)
Host E.coli
Konjugat/Tag Untagged
Purity > 95% by SDS-PAGE
Sequence MERASLIQKA KLAEQAERYE DMAAFMKGAV EKGEELSCEE RNLLSVAYKN VVGGQRAAWR VLSSIEQKSN EEGSEEKGPE VREYREKVET ELQGVCDTVL GLLDSHLIKE AGDAESRVFY LKMKGDYYRY LAEVATGDDK KRIIDSARSA YQEAMDISKK EMPPTNPIRL GLALNFSVFH YEIANSPEEA ISLAKTTFDE AMADLHTLSE DSYKDSTLIM QLLRDNLTLW TA
Citations Benzinger A., et al. (2005) Mol Cell Proteomics. 4(6): 785-95.
Wilker E W., et al. (2005) J Biol Chem. 280:18891-18898.

Arakawa N, et al. Serum stratifin and presepsin as candidate biomarkers for early detection of COVID-19 disease progression. (J Pharmacol Sci. 2022){https://pubmed.ncbi.nlm.nih.gov/35926945/}
Arakawa N, et al. Stratifin as a novel diagnostic biomarker in serum for diffuse alveolar damage. (Nat Commun. 2022){https://pubmed.ncbi.nlm.nih.gov/36195613/}
NCBI NP_006133
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias stratifin,Epithelial cell marker protein 1,HME1,YWHAS,SFN,14-3-3 sigma
Similar products SFN, HME1, Epithelial cell marker protein 1, 14-3-3 sigma, YWHAS, stratifin, 1433 sigma, ATGP0435-10ug, ATGP0435-20ug, ATGP0435-50ug, ATGP0435-100ug, ATGP0435-250ug, ATGP0435-500ug, ATGP0435-1mg, ATGP0435-10, ATGP0435-20, ATGP0435-50, ATGP0435-100, ATGP0435-250, ATGP0435-500, ATGP0435-1
Lieferbar
Manufacturer - Type
Recombinant Protein
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
27.7 kDa (248aa) confirmed by MALDI-TOF
Description
14-3-3 sigma, also known as Stratifin (SFN), belong to the 14-3-3 family. The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, beta, gamma, epsilon, sigma, zeta, tau and eta that have been identified in mammals. 14-3-3 sigma was identified as an epithelial cell marker and appeared to function as a tumor suppressor whose expression can be down regulated via methylation. Loss of 14-3-3 sigma expression results in a defective G2/M phase checkpoint and appears to contribute to both epithelial and non-epithelial tumorigenesis. Recombinant human 14-3-3 sigma was expressed in E. coli and purified by using conventional chromatography techniques.
Concentration
1mg/ml (determined by Bradford assay)
Formulation
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 50mM NaCl, 10% glycerol
Antigen Species
Human
Gene Category
Apoptosis
Domain
1-248aa
Species of Protein
Human
Manufacturer - Search Terms
1433 sigma, stratifin, Epithelial cell marker protein 1, HME1, YWHAS, SFN, 14-3-3 sigma, ATGP0435-10ug, ATGP0435-20ug, ATGP0435-50ug, ATGP0435-100ug, ATGP0435-250ug, ATGP0435-500ug, ATGP0435-1mg, ATGP0435-10, ATGP0435-20, ATGP0435-50, ATGP0435-100, ATGP0435-250, ATGP0435-500, ATGP0435-1

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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