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Recombinant human DKK1 protein

ArtNr NKM-ATGP2070-100ug
Hersteller NKMAX
Menge 100 ug
Quantity options 100 ug 20 ug 500 ug
Kategorie
Typ Proteins Recombinant
Format Liquid
Applikationen SDS-PAGE
Specific against Human (Homo sapiens)
Host E.coli
Konjugat/Tag HIS
Purity > 90% by SDS-PAGE
Sequence MGSSHHHHHH SSGLVPRGSH MGSTLNSVLN SNAIKNLPPP LGGAAGHPGS AVSAAPGILY PGGNKYQTID NYQPYPCAED EECGTDEYCA SPTRGGDAGV QICLACRKRR KRCMRHAMCC PGNYCKNGIC VSSDQNHFRG EIEETITESF GNDHSTLDGY SRRTTLSSKM YHTKGQEGSV CLRSSDCASG LCCARHFWSK ICKPVLKEGQ VCTKHRRKGS HGLEIFQRCY CG
Citations Ahn V.E., et al. (2011) Dev. Cell. 21:862-873
Haniu M., et al. (2011) Protein Sci. 20:1802-1813
NCBI NP_036374
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias Dickkopf WNT signaling pathway inhibitor 1,Dickkopf-related protein 1,Dickkopf-1,Dkk-1,SK
Similar products DKK1, DKK-1, SK, Xenopus laevis, Dickkopf-related protein 1, Dickkopf-1, hDkk-1, Dickkopf 1, Dickkopf homolog 1, Dickkopf related protein 1, DKK 1, hDkk 1, hDkk1, Dickkopf 1 homolog, Dickkopf 1 like, Dickkopf-related protein 1 Dickkopf 1, ATGP2070-10ug, ATGP2070-20ug, ATGP2070-50ug, ATGP2070-100ug, ATGP2070-250ug, ATGP2070-500ug, ATGP2070-1mg, ATGP2070-010, ATGP2070-020, ATGP2070-050, ATGP2070-100, ATGP2070-250, ATGP2070-500, ATGP2070-01M
Lieferbar
Manufacturer - Type
Recombinant Protein
Manufacturer - Applications
SDS-PAGE, Denatured
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
28.2 kDa (258aa)
Description
Dickkopf-related protein 1, also known as DKK1, antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Recombinant human DKK1 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Concentration
1mg/ml (determined by Bradford assay)
Formulation
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
Antigen Species
Human
Gene Category
Development
Domain
32-266aa
Species of Protein
Human
Manufacturer - Search Terms
Dickkopf 1, Dickkopf 1 homolog, Dickkopf 1 like, Dickkopf homolog 1, Dickkopf related protein 1, Dickkopf-1, Dickkopf-related protein 1, Dickkopf-related protein 1 Dickkopf 1, DKK 1, DKK1, DKK-1, hDkk 1, hDkk1, hDkk-1, SK, Xenopus laevis, ATGP2070-10ug, ATGP2070-20ug, ATGP2070-50ug, ATGP2070-100ug, ATGP2070-250ug, ATGP2070-500ug, ATGP2070-1mg, ATGP2070-010, ATGP2070-020, ATGP2070-050, ATGP2070-100, ATGP2070-250, ATGP2070-500, ATGP2070-01M

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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