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Recombinant human Parkin protein

ArtNr NKM-ATGP2517-100ug
Hersteller NKMAX
Menge 100 ug
Quantity options 100 ug 20 ug 500 ug
Kategorie
Typ Proteins Recombinant
Format Liquid
Applikationen SDS-PAGE
Specific against Human (Homo sapiens)
Host E.coli
Konjugat/Tag HIS
Purity > 80% by SDS-PAGE
Sequence MGSSHHHHHH SSGLVPRGSH MIVFVRFNSS HGFPVEVDSD TSIFQLKEVV AKRQGVPADQ LRVIFAGKEL RNDWTVQNCD LDQQSIVHIV QRPWRKGQEM NATGGDDPRN AAGGCEREPQ SLTRVDLSSS VLPGDSVGLA VILHTDSRKD SPPAGSPAGR SIYNSFYVYC KGPCQRVQPG KLRVQCSTCR QATLTLTQGP SCWDDVLIPN RMSGECQSPH CPGTSAEFFF KC
Citations Imai Y., et al. (2000) J. Biol. Chem. 275:35661-35664
Shimura H., et al. (2000) Nat. Genet. 25:302-305
NCBI NP_004553.2
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias E3 ubiquitin-protein ligase parkin,AR-JP,LPRS2,PDJ,PRKN
Similar products Parkin, PRKN, E3 ubiquitin-protein ligase parkin, AR-JP, LPRS2, PDJ, ATGP2517-10ug, ATGP2517-20ug, ATGP2517-50ug, ATGP2517-100ug, ATGP2517-250ug, ATGP2517-500ug, ATGP2517-1mg, ATGP2517-10, ATGP2517-20, ATGP2517-50, ATGP2517-100, ATGP2517-250, ATGP2517-500, ATGP2517-1
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Manufacturer - Type
Recombinant Protein
Manufacturer - Applications
SDS-PAGE, Denatured
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
53.8 kDa (485aa)
Description
The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. Recombinant human PARK2 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Concentration
1mg/ml (determined by Bradford assay)
Formulation
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
Antigen Species
Human
Gene Category
Metabolism
Domain
1-465aa
Species of Protein
Human
Manufacturer - Search Terms
Parkin, E3 ubiquitin-protein ligase parkin, AR-JP, LPRS2, PDJ, PRKN, ATGP2517-10ug, ATGP2517-20ug, ATGP2517-50ug, ATGP2517-100ug, ATGP2517-250ug, ATGP2517-500ug, ATGP2517-1mg, ATGP2517-10, ATGP2517-20, ATGP2517-50, ATGP2517-100, ATGP2517-250, ATGP2517-500, ATGP2517-1

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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