Vergleich

Recombinant HCV E2 protein

ArtNr NKM-ATGP2758-100ug
Hersteller NKMAX
Menge 100 ug
Quantity options 100 ug 20 ug 500 ug
Kategorie
Typ Proteins Recombinant
Format Liquid
Applikationen SDS-PAGE
Specific against HCV (Hepatitis C virus)
Host E.coli
Konjugat/Tag HIS
Purity > 80% by SDS-PAGE
Sequence MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSERPY CWHYPPRPCG IVPAKSVCGP VYCFTPSPVV VGTTDRSGAP TYSWGANDTD VFVLNNTRPP LGNWFGCTWM NSTGFTKVCG APPCVIGGVG NNTLLCPTDC FRKHPEATYS RCGSGPWITP RCMVDYPYRL WHYPCTINYT IFKVRMYVGG VEHRLEAACN WTRGERCDLE DRDRSELSPL LLSTTQ
Citations Taylor D.R., et al. (2001) J. Virol. 75:1265-1273
Kalliampakou K.I., et al. (2015) J. Gen. Virol. 86:1015-1025
NCBI NP_671491
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias Polyprotein
Similar products HCV, HCV E2, Polyprotein, ATGP2758-10ug, ATGP2758-20ug, ATGP2758-50ug, ATGP2758-100ug, ATGP2758-250ug, ATGP2758-500ug, ATGP2758-1mg, ATGP2758-10, ATGP2758-20, ATGP2758-50, ATGP2758-100, ATGP2758-250, ATGP2758-500, ATGP2758-1
Lieferbar
Manufacturer - Type
Recombinant Protein
Manufacturer - Applications
SDS-PAGE, Denatured
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
25.4 kDa (226aa)
Description
E1 and E2 glycoproteins form a heterodimer that is involved in virus attachment to the host cell, virion internalization through clathrin-dependent endocytosis and fusion with host membrane. E1/E2 heterodimer binds to human LDLR, CD81 and SCARB1/SR-BI receptors, but this binding is not sufficient for infection, some additional liver specific cofactors may be needed. The fusion function may possibly be carried by E1. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells. Recombinant HCV (Hepatitis C Virus) E2 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Concentration
0.25mg/ml (determined by Bradford assay)
Formulation
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
Antigen Species
HCV
Gene Category
Virus
Domain
482-671aa
Species of Protein
HCV
Manufacturer - Search Terms
HCV, HCV E2, Polyprotein, ATGP2758-10ug, ATGP2758-20ug, ATGP2758-50ug, ATGP2758-100ug, ATGP2758-250ug, ATGP2758-500ug, ATGP2758-1mg, ATGP2758-10, ATGP2758-20, ATGP2758-50, ATGP2758-100, ATGP2758-250, ATGP2758-500, ATGP2758-1

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
lieferbar

Vergleichen

Auf den Wunschzettel

Angebot anfordern

Lieferzeit anfragen

Technische Frage stellen

Bulk-Anfrage stellen

Fragen zum Produkt?
 
Schließen