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Recombinant mouse Cystatin C protein

ArtNr NKM-ATGP3569-10ug
Hersteller NKMAX
Menge 10 ug
Quantity options 100 ug 10 ug 20 ug 250 ug 500 ug 50 ug
Kategorie
Typ Proteins Recombinant
Format Liquid
Applikationen SDS-PAGE
Specific against Mouse (Murine, Mus musculus)
Host Baculovirus-Infected Insect Cells
Konjugat/Tag HIS
Purity > 95% by SDS-PAGE
Sequence ATPKQGPRML GAPEEADANE EGVRRALDFA VSEYNKGSND AYHSRAIQVV RARKQLVAGV NYFLDVEMGR TTCTKSQTNL TDCPFHDQPH LMRKALCSFQ IYSVPWKGTH SLTKFSCKNA <HHHHHH>
Citations Janowski. R., et al. (2001) Nat. Struct. Biol. 8(4):316-20.
Mussap M., et al. (2004) Crit Rev Clin Lab Sci. 41(5-6):467-550.
NCBI NP_034106
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias CST3,CysC
Similar products CST3, Cystatin C, CysC, ATGP3569-10ug, ATGP3569-20ug, ATGP3569-50ug, ATGP3569-100ug, ATGP3569-250ug, ATGP3569-500ug, ATGP3569-1mg, ATGP3569-10, ATGP3569-20, ATGP3569-50, ATGP3569-100, ATGP3569-250, ATGP3569-500, ATGP3569-1
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Manufacturer - Type
Recombinant Protein
Manufacturer - Applications
SDS-PAGE, Enzyme Activity
Manufacturer - Host
Baculovirus
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
14.2 kDa (126aa) confirmed by MALDI-TOF
Description
CST3, also known as Cystatin-C is a member of family 2 of the cystatin superfamily. This protein is a secreted type 2 cysteine protease inhibitor synthesized in all nucleated cells, has been proposed as a replacement for serum creatinine for the assessment of renal function, particularly to detect small reductions in glomerular filtration rate. It is involved in processes such as tumor invasion and metastasis, inflammation and some neurological diseases. It inhibits many cysteine proteases such as papain and cathepsins B, H, K, L and S. It indicates that a murine model should be relevant for studies of the human disease, hereditary Cystatin C amyloid angiopathy. Recombinant Mouse CST3, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Concentration
1mg/ml (determined by absorbance at 280nm)
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Antigen Species
Mouse
Gene Category
Signal Transduction
Domain
21-140aa
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Bioactivity Comment Only
The IC50 value is < 1.0nM. The inhibitory function of Cystatin 3 on protease activity of papain was measured by a fluorometric assay using Z-FR-AMC at pH 7.5 at 25C
Predicted nterm
Ala21
Species of Protein
Mouse
Manufacturer - Search Terms
Cystatin C, CST3, CysC, ATGP3569-10ug, ATGP3569-20ug, ATGP3569-50ug, ATGP3569-100ug, ATGP3569-250ug, ATGP3569-500ug, ATGP3569-1mg, ATGP3569-10, ATGP3569-20, ATGP3569-50, ATGP3569-100, ATGP3569-250, ATGP3569-500, ATGP3569-1

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Menge: 10 ug
Lieferbar: In stock
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