Rabbit antibody to c Fos

FUNCTION: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.
SUBUNIT: Heterodimer. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA. Interacts with MAFB
SUBCELLULAR LOCATION: Nucleus.
INDUCTION: C-fos expression increases upon a variety of stimuli, including growth factors, cytokines, neurotransmitters, polypeptide hormones, stress and cell injury.
SIMILARITY: Belongs to the bZIP family. Fos subfamily
SIMILARITY: Contains 1 bZIP domain

IHC, WB. Use at a dilution of 1 : 1000 for IHC-P and 1 : 2000 for WB. The optimal dilution should be determined by the end user. IMPORTANT: The lysate must be prepared in Ripa buffer containing 1% Triton-X100; 1% SDS and 1% SDC.

12 months after purchase

1. Hai T, et al. Genes Dev. 3:2083-2090(1989).
2. Heilig R, et al. Nature 421:601-607(2003).

A synthetic peptide from rat c Fos protein conjugated to blue carrier protein has been used as the antigen. The peptide is homologous in mouse and human.

http://ca.expasy.org/uniprot/Q4FDN1
http://ca.expasy.org/uniprot/P01101
http://www.uniprot.org/uniprot/P01100

Polyclonal antibody

Lyophilised