Comparison

Rabbit antibody to c Fos

Item no. OSC00040W
Manufacturer Osenses
Amount 100ul
Category
Type Antibody Polyclonal
Applications WB, IHC
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host Rabbit
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Proto-oncogene protein cFOS, c-Fos
Similar products c-Fos, Proto-oncogene protein cFOS
Available
Also known
Proto-oncogene protein cFOS, c-Fos
Target
FUNCTION: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.
SUBUNIT: Heterodimer. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA. Interacts with MAFB
SUBCELLULAR LOCATION: Nucleus.
INDUCTION: C-fos expression increases upon a variety of stimuli, including growth factors, cytokines, neurotransmitters, polypeptide hormones, stress and cell injury.
SIMILARITY: Belongs to the bZIP family. Fos subfamily
SIMILARITY: Contains 1 bZIP domain
Spcs X-react.
Rat, mouse, human. Other species not yet tested.
Applications info
IHC, WB. Use at a dilution of 1 : 1000 for IHC-P and 1 : 2000 for WB. The optimal dilution should be determined by the end user. IMPORTANT: The lysate must be prepared in Ripa buffer containing 1% Triton-X100; 1% SDS and 1% SDC.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after purchase
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Hai T, et al. Genes Dev. 3:2083-2090(1989).
2. Heilig R, et al. Nature 421:601-607(2003).
Limitation
For research use only
Immunogen
A synthetic peptide from rat c Fos protein conjugated to blue carrier protein has been used as the antigen. The peptide is homologous in mouse and human.
Conjugate
Unconjugated antibody
Accession
http://ca.expasy.org/uniprot/Q4FDN1
http://ca.expasy.org/uniprot/P01101
http://www.uniprot.org/uniprot/P01100
Purity
Whole serum
Clonality
Polyclonal antibody
Specificity
Specific for cFOS.
Format
Lyophilised
Reconstitution
Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100ul
Available: In stock
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