Rabbit antibody to KCNJ10 (330-379)

FUNCTION: May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium.
Subcellular location: Membrane, Multi-pass membrane protein.

IHC, WB. A concentration of 10-50 ug/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.

12 months after reconstitution

1. Shuck M.E, et al. J. Biol. Chem. 272:586-593(1997)
2. Schoots O, et al. Cell. Signal. 11:871-883(1999)

A synthetic peptide from aa region 330-379 of human KCNJ10 conjugated to blue carrier protein was used as the antigen.

http://www.uniprot.org/uniprot/P78508
http://www.uniprot.org/uniprot/Q9JM63
http://www.uniprot.org/uniprot/P49655

Polyclonal

Lyophilised