Rabbit antibody to PIST

Function: Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ACCN3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.
SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus a€C trans-Golgi network membrane; Peripheral membrane protein. Cell junction a€C synapse. Cell junction a€C synapse a€C postsynaptic cell membrane a€C postsynaptic density. Cell projection a€C dendrite. Note: Enriched in synaptosomal and postsynaptic densities (PSD) fractions . Expressed in cell bodies and dendrites of Purkinje cells. Localized at the trans-Golgi network (TGN) of spermatids and the medulla of round spermatides
Tissue specificity: Ubiquitously expressed.

IHC, WB. Use at a dilution of 1:1000 to 1:2000. The optimal dilution should be determined by the end user.

12 months after reconstitution

1. Charest A, et al. J. Biol. Chem. 276:29456-29465(2001)

A synthetic peptide from rat PIST conjugated to blue carrier protein has been used as the antigen.

http://www.uniprot.org/uniprot/Q9HD26
http://www.uniprot.org/uniprot/Q8BH60
http://www.uniprot.org/uniprot/D3ZFM6

Polyclonal

Lyophilised