Vergleich

Rabbit antibody to Tau (640-680)

ArtNr OST00329W
Hersteller Osenses
Menge 150ul
Kategorie
Typ Antibody Polyclonal
Applikationen WB, IHC
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host Rabbit
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, MAPT, MAPTL, MTBT1
Similar products MAPT, MAPTL, MTBT1, Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau
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Also known
Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, MAPT, MAPTL, MTBT1
Target
Function: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Subcellular location: Cytoplasm a€C cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm a€C cytoskeleton. Cell projection a€C axon. Note: Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.
Tissue specificity: Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.
Spcs X-react.
Human, rat, mouse. Other species not yet tested.
Applications info
IHC, WB. A dilution of 1 : 3000 is recommended for WB and 1 : 1000 for IHC-P. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Goedert M, et al. Proc. Natl. Acad. Sci. U.S.A. 85:4051-4055(1988)
Limitation
For research use only
Immunogen
A synthetic peptide from aa region 640-680 of human Tau conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
Conjugate
Unconjugated antibody
Accession
http://www.uniprot.org/uniprot/P10636
http://www.uniprot.org/uniprot/P10637
http://www.uniprot.org/uniprot/P19332
Purity
Whole serum
Clonality
Polyclonal
Specificity
Specific for Tau.
Format
Lyophilised. This product contains 0.02% benzalkonium chloride as a preservative.
Reconstitution
Reconstitute in 150 ul of sterile water. Centrifuge to remove any insoluble material.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 150ul
Lieferbar: In stock
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