Rabbit antibody to Tau (640-680)

Function: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Subcellular location: Cytoplasm a€C cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm a€C cytoskeleton. Cell projection a€C axon. Note: Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.
Tissue specificity: Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.

IHC, WB. A dilution of 1 : 3000 is recommended for WB and 1 : 1000 for IHC-P. The optimal dilution should be determined by the end user. Not yet tested in other applications.

12 months after reconstitution

1. Goedert M, et al. Proc. Natl. Acad. Sci. U.S.A. 85:4051-4055(1988)

A synthetic peptide from aa region 640-680 of human Tau conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse.

http://www.uniprot.org/uniprot/P10636
http://www.uniprot.org/uniprot/P10637
http://www.uniprot.org/uniprot/P19332

Polyclonal

Lyophilised. This product contains 0.02% benzalkonium chloride as a preservative.