Rabbit antibody to ATG16L1

FUNCTION: Plays an essential role in autophagy.
SUBUNIT: Homooligomer. Interacts with ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa).
SUBCELLULAR LOCATION: Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein. Note: Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5.
DISEASE: Genetic variations in ATG16L1 are associated with susceptibility to inflammatory bowel disease type 10 (IBD10). IBD is characterized by a chronic relapsing intestinal inflammation. IBD is subdivided into Crohn disease (CD) and ulcerative colitis phenotypes. IBD10 individuals show the phenotype characteristic to CD. It may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. CD is commonly classified as autoimmune disease.

IHC, WB. Use at a dilution of 1 : 100 to 1 : 2000. The optimal dilution should be determined by the end user.

12 months after reconstitution

1. Van Limbergen J, et al. Inflamm. Bowel Dis. 14 (3), 338-346(2008).
2. Perricone C, et al. Gastroenterology 134 (1), 368-370(2008).
3. Massey D.C et al. Autophagy 3 (6), 649-651(2007).

A synthetic peptide from human ATG16L1 conjugated to blue carrier protein has been used as the antigen. The peptide is homologous in mouse and rat.

http://br.expasy.org/uniprot/Q676U5
ATG16L1_HUMAN <||/au http://br.expasy.org/uniprot/Q5RAC9

Polyclonal

Lyophilised