Rabbit antibody to TRPM4

FUNCTION: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.

IHC, WB. A dilution of 1 : 500 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

12 months after reconstitution

1. Gibbs R.A, et al. Nature 428:493-521(2004)

A synthetic peptide from mouse TRPM4 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat.

http://ca.expasy.org/uniprot/Q9ESQ5
http://ca.expasy.org/uniprot/Q7TN37

Polyclonal

Lyophilised