Comparison

Rabbit antibody to TRPM4

Item no. OST00305W
Manufacturer Osenses
Amount 100ul
Category
Type Antibody Polyclonal
Applications WB, IHC
Specific against Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host Rabbit
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Transient receptor potential cation channel subfamily M member 4, Long transient receptor potential channel 4, Calcium-activated non-selective cation channel 1, Melastatin-like 2, MLS2s
Similar products Transient receptor potential cation channel subfamily M member 4, Calcium-activated non-selective cation channel 1, Long transient receptor potential channel 4, Melastatin-like 2, MLS2s
Available
Also known
Transient receptor potential cation channel subfamily M member 4, Long transient receptor potential channel 4, Calcium-activated non-selective cation channel 1, Melastatin-like 2, MLS2s
Target
FUNCTION: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Spcs X-react.
Rat, mouse. Other species not yet tested.
Applications info
IHC, WB. A dilution of 1 : 500 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Gibbs R.A, et al. Nature 428:493-521(2004)
Limitation
For research use only
Immunogen
A synthetic peptide from mouse TRPM4 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat.
Conjugate
Unconjugated antibody
Accession
http://ca.expasy.org/uniprot/Q9ESQ5
http://ca.expasy.org/uniprot/Q7TN37
Purity
Whole serum
Clonality
Polyclonal
Specificity
Specific for TRPM4.
Format
Lyophilised
Reconstitution
Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100ul
Available: In stock
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