Alias |
A.11, AI528707, CD62 antigen ligand, CD62 antigen-like family member L, CD62L, gp90-MEL, IgA nephropathy, susceptibility to, included, L Selectin, L-selectin, LAM-1, LAM1, LECAM1, LEU8, Leukocyte adhesion molecule 1, Leukocyte surface antigen Leu-8, Leukocyte-endothelial cell adhesion molecule 1, Lnhr, LSEL, Ly-22, Ly-m22, Lyam-1, LYAM1, LYAM1, Lymph node homing receptor, Lymphocyte adhesion molecule 1, Lymphocyte antigen 22, Lymphocyte surface MEL-14 antigen, MEL-14, Pln homing receptor, PLNHR, Selectin L, Selectin, lymphocyte, SELL, TQ1 |
Background |
This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with an various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. |