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TRAF2 Antibody (Center) Blocking peptide

TRAF2 Antibody (Center) Blocking peptide

ArtNr	ABC-BP13857c
Hersteller	Abcepta
Menge	500 ug
Kategorie	Metabolism Diabetes Peptides & Proteins Cell Biology Cell Status Apoptosis Peptides
Typ	Peptides
Format	Lyophilized
Specific against	other
Citations	Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Song, Y.J., et al. Virus Genes 41(2):174-180(2010)Mace, P.D., et al. J. Mol. Biol. 400(1):8-15(2010)Alvarez, S.E., et al. Nature 465(7301):1084-1088(2010)Zhang, W., et al. Chin. Med. Sci. J. 25(1):1-12(2010)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	TNF receptor-associated factor 2,632-,E3 ubiquitin-protein ligase TRAF2,Tumor necrosis factor type 2 receptor-associated protein 3,TRAF2,TRAP3
Similar products	TRAF2, TRAP3, TNF receptor-associated factor 2, E3 ubiquitin-protein ligase TRAF2, Tumor necrosis factor type 2 receptor-associated protein 3, 632-
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Manufacturer - Category	Peptides; Blocking Peptides
Manufacturer - Targets	The synthetic peptide sequence used to generate the antibody AP13857c was selected from the Center region of TRAF2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Bio Background	The protein encoded by this gene is a member of the TNFreceptor associated factor (TRAF) protein family. TRAF proteinsassociate with, and mediate the signal transduction from members ofthe TNF receptor superfamily. This protein directly interacts withTNF receptors, and forms a heterodimeric complex with TRAF1. Thisprotein is required for TNF-alpha-mediated activation of MAPK8/JNKand NF-kappaB. The protein complex formed by this protein and TRAF1interacts with the inhibitor-of-apoptosis proteins (IAPs), andfunctions as a mediator of the anti-apoptotic signals from TNFreceptors. The interaction of this protein with TRADD, a TNFreceptor associated apoptotic signal transducer, ensures therecruitment of IAPs for the direct inhibition of caspaseactivation. BIRC2/c-IAP1, an apoptosis inhibitor possessingubiquitin ligase activity, can unbiquitinate and induce thedegradation of this protein, and thus potentiate TNF-inducedapoptosis. Multiple alternatively spliced transcript variants havebeen found for this gene, but the biological validity of only onetranscript has been determined.
Gene Name	TRAF2 {ECO:0000303\|PubMed:28489822, ECO:0000312\|HGNC:HGNC:12032}
Subtitle	Synthetic peptide
Formulation	Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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ABC-BP13857c-datasheet.pdf

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Menge: 500 ug

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Lieferung vsl. bis 01.01.2026

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