TRAF2 Antibody (Center) Blocking peptide

Peptides; Blocking Peptides

The protein encoded by this gene is a member of the TNFreceptor associated factor (TRAF) protein family. TRAF proteinsassociate with, and mediate the signal transduction from members ofthe TNF receptor superfamily. This protein directly interacts withTNF receptors, and forms a heterodimeric complex with TRAF1. Thisprotein is required for TNF-alpha-mediated activation of MAPK8/JNKand NF-kappaB. The protein complex formed by this protein and TRAF1interacts with the inhibitor-of-apoptosis proteins (IAPs), andfunctions as a mediator of the anti-apoptotic signals from TNFreceptors. The interaction of this protein with TRADD, a TNFreceptor associated apoptotic signal transducer, ensures therecruitment of IAPs for the direct inhibition of caspaseactivation. BIRC2/c-IAP1, an apoptosis inhibitor possessingubiquitin ligase activity, can unbiquitinate and induce thedegradation of this protein, and thus potentiate TNF-inducedapoptosis. Multiple alternatively spliced transcript variants havebeen found for this gene, but the biological validity of only onetranscript has been determined.

Synthetic peptide