UCP1 Blocking Peptide(C-term)

Peptides; Blocking Peptides

Mitochondrial uncoupling proteins (UCP) are members of thefamily of mitochondrial anion carrier proteins (MACP). UCPsseparate oxidative phosphorylation from ATP synthesis with energydissipated as heat, also referred to as the mitochondrial protonleak. UCPs facilitate the transfer of anions from the inner to theouter mitochondrial membrane and the return transfer of protonsfrom the outer to the inner mitochondrial membrane. They alsoreduce the mitochondrial membrane potential in mammalian cells.Tissue specificity occurs for the different UCPs and the exactmethods of how UCPs transfer H+/OH- are not known. UCPs contain thethree homologous protein domains of MACPs. This gene is expressedonly in brown adipose tissue, a specialized tissue which functionsto produce heat.

Synthetic peptide