MOG 35-55

Peptides

Store dry at -20°C

H

Myelin oligodendrocyte glycoprotein (MOG) 35-55, a minor component of CNS myelin, is expressed in central nervous system myelin which produces a relapsing-remitting neurological diesease with extensive plaque-like demyelination. It is believed to be a target autoantigen in multiple sclerosis. MOG 35-55 peptide is an immunodominant epitope of MOG that induces strong T and B cell responses and experimental autoimmune encephalomyelitis in rodents. A single injection of this peptide produces a relapsing-remitting neurologic disease with extensive plaque-like demyelination. This Cysteine containing MOG (35-55) peptide can be used to induce polyclonal anti-MOG(35-55) antibody production in rabbits with high specificity, high affinity, and high titer indicating its high purity, as well as suitability for peptide-coated ELISA and Western blot assay. Immunization with MOG (35-55) suppresses spontaneous regeneration of dopaminergic neurons injured with MPTP.

Myelin oligodendrocyte glycoprotein