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Human cytomegalovirus (strain Merlin) (HHV-5) Envelope protein H&L&UL128&UL130&UL131, Twin-Streptavidin Tag&His Tag (MALS verified)

Human cytomegalovirus (strain Merlin) (HHV-5) Envelope protein H&L&UL128&UL130&UL131, Twin-Streptavidin Tag&His Tag (MALS verified)

ArtNr	ENN-V5283-50ug
Hersteller	ACROBiosystems
Menge	50 ug
Quantity options	500 ug 50 ug
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Solid
Specific against	Human (Homo sapiens), Virus
Host	HEK293
Konjugat/Tag	Unconjugated, Streptavidin
Purity	90%
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Versandbedingung	Raumtemperatur
Lieferbar
Specificity	Human cytomegalovirus
Manufacturer - Category	Protein
Manufacturer - Conjugate / Tag	N-Twin streptavidin \| Native \| C-10xHis \| Native, Unconjugated
Shipping Temperature	RT
Storage Conditions	-20°C
Molecular Weight	110.8 kDa (H&L) & 16.7 kDa (UL128) & 23.7 kDa (UL130) & 13.0 kDa (UL131)
Manufacturer - Format	Powder
Description	Human cytomegalovirus (HCMV), a prototypical beta-herpes virus, is a major cause of morbidity and mortality in immunocompromised transplant recipients and congenitally infected fetuses.Different HCMV glycoprotein complexes are capable of meditating entry through interaction with cell-specific receptors on a panel of host cells. The pentamer (gH/gL/UL128/UL130/UL131A) mediates HCMV entry into epithelial, endothelial, and myeloid cells by its binding to neuropilin 2 (Nrp2). The trimer (gH/gL/gO) can mediate infection of all cell types by binding to platelet-derived growth factor-alpha (PDGFRα). Both pentamer and trimer need to interact with the glycoprotein B (gB), the fusogenic protein, to trigger the virus and host cell membrane fusion.
Background	Human cytomegalovirus (HCMV), a prototypical beta-herpes virus, is a major cause of morbidity and mortality in immunocompromised transplant recipients and congenitally infected fetuses.Different HCMV glycoprotein complexes are capable of meditating entry through interaction with cell-specific receptors on a panel of host cells. The pentamer (gH/gL/UL128/UL130/UL131A) mediates HCMV entry into epithelial, endothelial, and myeloid cells by its binding to neuropilin 2 (Nrp2). The trimer (gH/gL/gO) can mediate infection of all cell types by binding to platelet-derived growth factor-alpha (PDGFRα). Both pentamer and trimer need to interact with the glycoprotein B (gB), the fusogenic protein, to trigger the virus and host cell membrane fusion.
Molecule	Envelope protein H&L&UL128&UL130&UL131
Exp Region	Ala 31 - Arg 278 & Arg 24 - Leu 719 (H&L) & Glu 28 - Gln 171 (UL128) & Ser 26 - Val 214 (UL130) & Gln 19 - Asn 129 (UL131)
Characteristics	This protein carries a twin streptavidin tag and polyhistidine tag. The protein has a calculated MW of 110.8 kDa (H&L) & 16.7 kDa (UL128) & 23.7 kDa (UL130) & 13.0 kDa (UL131). The protein migrates as 15 kDa, 35 kDa and 130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin	1.0 EU per μg
Buffer	PBS, pH7.4
Stability	● -20°C to -70°C for 12 months in lyophilized state ● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant	trehalose

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ENN-V5283-50ug-datasheet.pdf

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Menge: 50 ug

lieferbar

Lieferung vsl. bis 19.02.2026