IRGM, Recombinant, Human, aa23-181, His-Tag (Immunity-related GTPase Family M Protein, IFI1, IRGM1, LRG-47, LRG47, MGC149263, MGC149264)

Blue Ice

20, 1

Supplied as a liquid in 20mM tris-HCl buffer, pH 8.0, 2M urea, 10% glycerol.

Immunity-related GTPase family M protein, also known as IRGM, is required for clearance of acute protozoan and bacterial infections. This protein functions in innate immune response probably through regulation of autophagy. It may regulate proinflammatory cytokine production and prevent endotoxemia upon infection and may also play a role in macrophages adhesion and motility.

Source:
Recombinant protein corresponding to aa23-181 from human IRGM at N-terminal, fused to His-tag expressed in E.coli.

Molecular Weight:
~20.1kD (180aa)

Amino Acid Sequence:
MGSSHHHHHH SSGLVPRGSH MKETLKIVSR TPVNITMAGD SGNGMSTFIS ALRNTGHEGK ASPPTELVKA TQRCASYFSS HFSNVVLWDL PGTGSATTTL ENYLMEMQFN RYDFIMVASA QFSMNHVMLA KTAEDMGKKF YIVWTKLDMD LSTGALPEVQ LLQIRENVLE NLQKERVCEY

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.