Rottlerin

Blue Ice

516, 54

Orange-brown powder

Rottlerin is an inhibitor of PRAK (IC50 1.9M), MAPKAP Kinase 2 (IC50 5.4M) and CaM Kinase III (3-6M). Rottlerin inhibits PMA-induced edema in mouse ear. For use as an Inhibitor of PRAK, MAPKAP kinase 2, and CaM Kinase III activity. Also shown to act as a direct mitochondrial uncoupler. Thought to stimulate autophagy by targeting upstream mTORC1 control pathways.

Synonyms:
(E)-1-[6-[(3-Acetyl-2, 4, 6-trihydroxy-5-methylphenyl)methyl]-5, 7-dihydroxy-2, 2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one; 3’-[(8-Cinnamoyl-5, 7-dihydroxy-2, 2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2’, 4’, 6’-trihydroxy-5’-methyl-acetophenone; (2E)-1-[6-[(3-Acetyl-2, 4, 6-trihydroxy-5-methylphenyl)methyl]-5, 7-dihydroxy-2, 2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one; Mallotoxin; NSC 56346; NSC 94525

CAS No:
82-08-6

Molecular Formula:
C30H28O8

Molecular Weight:
516.54

Appearance:
Orange-brown powder.

Purity:
≥95%

Melting Point:
200-205°C(lit.)

Solubility:
Soluble in DMSO, chloroform or 100% ethanol. Not soluble in water.

Warning!
Toxic. Wear gloves/mask when handling product. Avoid contact by all modes of exposure.

Storage and Stability:
Powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with DMSO, chloroform, or 100% ethanol. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.