Bak Rabbit pAb

Polyclonal Antibodies

Store at -20°C. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.

A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Bak (NP_001179.1).

23kDa

Cell Biology Developmental Biology, Apoptosis, Mitochondrial Control of Apoptosis, Endocrine Metabolism, Mitochondrial metabolism.

578

BAK1