Anti-GTP-binding protein Rheb Rheb Antibody

Primary Antibodies

20497 MW

Rheb antibody can be used for the detection of Rheb by Western blot at 2 and 4 μg/mL.
Antibody validated: Western Blot in rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Ras homolog enriched in brain

Rheb (Ras homolog enriched in brain) is an evolutionarily conserved member of the Ras family of small GTP-binding proteins originally found to be rapidly induced by synaptic activity in the hippocampus following seizure. While it is expressed at relatively high levels in the brain, Rheb is widely expressed in other tissues and may be induced by growth factor stimulation. Similar to other family members, Rheb triggers activation of the Raf-MEK-MAPK pathway. Biochemical and genetic studies demonstrate that Rheb has an important role in regulating the insulin/Target of rapamycin (TOR) signaling pathway. TOR is a serine/threonine protein kinase that acts as a sensor for ATP and amino acids, balancing the availability of nutrients with protein translation and cell growth. A dimeric protein complex termed TSC1/TSC2 indirectly inhibits TOR activity by inhibiting Rheb via the GAP activity of TSC2.

Rheb Antibody is supplied in PBS containing 0.02% sodium azide.

1 mg/mL

Ras homolog enriched in brain

Endomembrane system

Ubiquitous. Highest levels observed in
skeletal and cardiac muscle.

Post-translationally modified Rheb is sometimes observed at higher molecular weight.