Anti-IL-23 Antibody

ArtNr	BOS-A01097-2
Hersteller	Boster
Menge	0.1 mg
Quantity options	0.1 mg 0.1 mg
Kategorie	Cell Biology Cell Culture Cytokines Immunohistochemistry Western Blot ELISA Immunofluorescence Immunocytochemistry Immunostaining Immunochemistry
Format	Liquid
Applikationen	WB, IF, ELISA, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Alias	P19,SGRF,IL-23,IL-23A,IL23P19,UNQ2498/PRO5798,Interleukin-23 subunit alpha,Interleukin-23 subunit p19,IL-23 subunit alpha
Lieferbar
Manufacturer - Category	Primary Antibodies
Storage Conditions	IL-23 antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Molecular Weight	20730 MW
Clonality	Polyclonal
Application Details	WB: 0.25-2 μg/mL; IF: 20 μg/mL, IHC: 2 μg/mL. Antibody validated: Western Blot in human and mouse samples; Immunofluorescence and Immunohistochemistry in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Gene Name	IL23A
Gene Full Name	Interleukin 23, alpha subunit p19
Background	Like interleukin-27 (IL-27), IL-23 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the IL-12p40 subunit and a novel p19 subunit. IL-23 is secreted by activated dendritic cells, macrophages, and monocytes. Its biological activities include enhancing the proliferation of memory T cells and the production of IFN-gamma, IL-12, and TNF-α from activated T cells, and can stimulate macrophages to produce TNF-α and nitric oxide. It has also been shown to possess potent anti-tumor and anti-metastatic activity in mouse models of cancer, suggesting a potential role for IL-23 in therapeutic treatment of cancer.
Immunogen	Anti-IL-23 antibody was raised against a peptide corresponding to 17 amino acids near the amino terminus of human IL-23. The immunogen is located within amino acids 40 - 90 of IL-23.
Contents	IL-23 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification	IL-23 Antibody is affinity chromatography purified via peptide column.
Concentration	1 mg/mL
Manufacturer - Research Category	Immunology, Chemokines, Cytokines, Neuroscience
Protein Name	Interleukin 23, alpha subunit p19
Protein Function	Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak- Stat signaling cascade, stimulates memory rather than naive T- cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Subcellular Localization	Secreted
Description	Boster Bio Anti-IL-23 Antibody (Catalog # A01097-2). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.
Tissue Specificity	Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).
Predicted Reactivity	Horse, Pig, Rat, Guinea Pig

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BOS-A01097-2-datasheet.pdf

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