Anti-LAMP-2 Antibody

LAMP-2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Polyclonal

LAMP2

LAMP-2 antibody cross reacts with LAMP2B and LAMP2C, but not LAMP2A.

LAMP-2 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human LAMP-2. The immunogen is located within the last 50 amino acids of LAMP-2.

LAMP-2 Antibody is affinity chromatography purified via peptide column.

Apoptosis, Autophagy

Plays an important role in chaperone-mediated autophagy,
a process that mediates lysosomal degradation of proteins in
response to various stresses and as part of the normal turnover of
proteins with a long biological half-live (PubMed:10972293).
Functions by binding target proteins, such as GAPDH and MLLT11,
and targeting them for lysosomal degradation (By similarity).
Required for the fusion of autophagosomes with lysosomes during
autophagy (PubMed:27628032). Cells that lack LAMP2 express normal
levels of VAMP8, but fail to accumulate STX17 on autophagosomes,
which is the most likely explanation for the lack of fusion
between autophagosomes and lysosomes (PubMed:27628032). Required
for normal degradation of the contents of autophagosomes
(PubMed:10972293, PubMed:12221139). Plays a role in lysosomal
protein degradation in response to starvation (PubMed:27628032).
Required for efficient MHCII-mediated presentation of exogenous
antigens via its function in lysosomal protein degradation;
antigenic peptides generated by proteases in the
endosomal/lysosomal compartment are captured by nascent MHCII
subunits. Is not required for efficient MHCII-mediated
presentation of endogenous antigens (By similarity).

Boster Bio Anti-LAMP-2 Antibody (Catalog # A01573). Tested in ELISA, WB, ICC, IHC-P applications. This antibody reacts with Human, Mouse.

Chicken, Rat, Bovine