Anti-TWEAK TNFSF12 Antibody

TWEAK antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Polyclonal

TNFSF12

TNF-related weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily (TNFSF) of structurally related cytokines. Like most other members of this family, TWEAK is a cell surface-associated type II transmembrane protein although a smaller, biologically active form can also be generated by cleavage near the cell membrane. TWEAK has multiple biological activities, including stimulation of cell growth and angiogenesis, induction of inflammatory cytokines, in addition to stimulation of apoptosis. The TWEAK signal transduction pathway has not been well established but it appears to signal via TweakR/Fn14 in a manner similar to that described for other TNFSF members that bind receptors lacking death domains.

TWEAK Antibody is supplied in PBS containing 0.02% sodium azide.

1 mg/mL

Tumor necrosis factor (ligand) superfamily, member 12

Cell membrane

Highly expressed in adult heart, pancreas,
skeletal muscle, brain, colon, small intestine, lung, ovary,
prostate, spleen, lymph node, appendix and peripheral blood
lymphocytes. Low expression in kidney, testis, liver, placenta,
thymus and bone marrow. Also detected in fetal kidney, liver, lung
and brain.