Ionomycin

ArtNr	HY-13434-10mg
Hersteller	MedChem Express
CAS-Nr.	56092-81-0
Menge	10 mg (14.1 mM x 1 mL in Ethanol)
Quantity options	10 mg (14.1 mM x 1 mL in Ethanol) 1 mg (14.1 mM x 100 uL in Ethanol) 5 mg (14.1 mM x 500 uL in Ethanol)
Kategorie	Reagents & Chemicals Biochemicals
Typ	Chemicals
Specific against	other
Purity	99.27
Citations	[1]Liu C,et al. Characterization of ionomycin as a calcium ionophore. J Biol Chem. 1978 Sep 10;253(17):5892-4.\|[2]Chatila T, et al. Mechanisms of T cell activation by the calcium ionophore ionomycin. J Immunol. 1989 Aug 15;143(4):1283-9.\|[3]Gil-Parrado S, et al. Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members. J Biol Chem. 2002 Jul 26;277(30):27217-26.\|[4]Stoeck A, et al A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44. Biochem J. 2006 Feb 1;393(Pt 3):609-18.\|[5]Junsuke Uwada, et al. Store-operated calcium entry (SOCE) contributes to phosphorylation of p38 MAPK and suppression of TNF-α signalling in the intestinal epithelial cells. Cell Signal. 2019 Nov;63:109358. ACS Infect Dis. 2023 Mar 14.\|Acta Pharm Sin B. 2024 Jun 20.\|Acta Pharmacol Sin. 2022 Sep 23.\|Adv Sci (Weinh). 2023 Jan 15;e2203869.\|Adv Sci (Weinh). 2024 Mar 14:e2306378.\|Adv Sci (Weinh). 2024 May 5:e2400297.\|Aging. 2019 Aug 19;11(16):6490-6502.\|Aging. 2021 Jun 2;13(11):15638-15658.\|Aging. 2021 Mar 24;13(7):10312-10325.\|Arch Oral Biol. 2024 Jul 3:166:106043.\|Biochem Pharmacol. 2023 Dec 2:115957.\|Biomed Pharmacother. 2022 Jan 17;147:112644.\|Biomed Pharmacother. 2024 Apr 17:174:116551.\|BMC Med. 2023 Dec 20;21(1):507.\|Cancer Cell. 2023 Jun 12;41(6):1170-1185.e12.\|Cancer Commun (Lond). 2022 Jan 3.\|Cancer Res. 2023 Jan 12;CAN-22-2405.\|Cell Calcium. 2022 Jun;104:102571.\|Cell Death Dis. 2021 Apr 1;12(4):336.\|Cell Metab. 2024 Jun 18:S1550-4131(24)00189-X.\|Cell Mol Immunol. 2022 Feb 22.\|Cell Rep. 2021 Jul 20;36(3):109404.\|Cell Rep. 2024 Mar 23;43(4):114003.\|Cell Res. 2025 Feb;35(2):97-116.\|Cytotechnology. 2024 Apr 24:1-8.\|EBioMedicine. 2024 Aug 6:106:105269.\|Ecotoxicol Environ Saf. 2023 Dec 14:115831.\|Eur J Pharmacol. 2021 Nov 9;174623.\|Evid-Based Compl Alt. 2021 Jan 7.\|Fish Shellfish Immunol. 2024 Mar 16:109515.\|Fish Shellfish Immunol. 2024 Oct 18:109975.\|Front Immunol. 05 August 2022.\|Gut Microbes. 2024 Jan-Dec;16(1):2410474.\|Hum Reprod. 2024 Feb 9:deae018.\|Int Immunopharmacol. 2023 Sep 1;124(Pt A):110865.\|Int Immunopharmacol. 2024 Sep 16;142(Pt B):113170.\|Int J Biol Macromol. 2023 Jun 13;125373.\|Int J Mol Sci. 2023 Aug 8, 24(16), 12557.\|J Cell Mol Med. 2024 Aug;28(15):e18589.\|J Cell Mol Med. 2025 Feb;29(3):e70403.\|J Ethnopharmacol. 2022 Dec 8;303:116031.\|J Immunol. 2021 Mar 1;206(5):963-977.\|J Immunother Cancer. 2024 Dec 9;12(12):e009910.\|J Nanobiotechnology. 2024 Sep 12;22(1):556.\|J Neuroimmunol. 2020 Aug 15;345:577286.\|J Periodontol. 2024 Aug 29.\|J Transl Med. 2024 Dec 20;22(1):1125.\|Microorganisms. 2023 Feb 27.\|Mol Cell. 2022 May 5;S1097-2765(22)00327-6.\|Mol Med. 2024 Jul 30;30(1):110.\|Nat Commun. 2023 Feb 23;14(1):1020.\|Nat Commun. 2025 Mar 19;16(1):2728.\|Oncol Rep. 2024 Feb;51(2):29.\|PLoS Pathog. 2025 Feb 4;21(2):e1012912.\|Preprints. 2023 Mar 6.\|Proc Natl Acad Sci U S A. 2022 Feb 22;119(8):e2114851119.\|Protein Cell. 2021 Oct 22;1-21.\|Redox Biol. 2023 Nov 10, 102959.\|Reprod Fert Develop. 33(2) 108-108.\|Research Square Preprint. 2023 Aug 11.\|Research Square Print. 2022 Jun.\|Sci Signal. 2023 Feb 28;16(774):eadd0645.\|Sci Total Environ. 2021, 146523.\|Sci Transl Med. 2020 Nov 25;12(571):eaaz6667.\|Theranostics. 2023 May 8;13(9):2879-2895.\|Vaccines. 2023 May 25, 11(6), 1026.\|Immunobiology. 2024 Sep 16.\|Int Immunopharmacol. 2023 Nov 16:126:111212.\|OncoImmunology. 2023 Oct 12;12(1):2268257.
Smiles	O=C(O)CC[C@@H](C)C[C@H](C)C[C@H](C)C(/C=C(O)/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]1CC[C@]([C@@H]2O[C@](C)([C@H](O)C)CC2)(C)O1)=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	SQ23377
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Natural Products
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Antibiotic; Apoptosis; Bacterial; Calcium Channel; PKC
Shipping Temperature	Blue Ice
Storage Conditions	Solution, -20°C, 2 years
Molecular Weight	709.01
Product Description	Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC)[1][2][3].
Manufacturer - Research Area	Cancer; Infection
Solubility	DMSO: 100 mg/mL (ultrasonic)\|Ethanol: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Apoptosis; Epigenetics; Membrane Transporter/Ion Channel; Neuronal Signaling; TGF-beta/Smad
Clinical information	No Development Reported

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HY-13434-10mg-safety-datasheet.pdf