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NB-598 (Maleate)

NB-598 (Maleate)

ArtNr	HY-16343C-2mg
Hersteller	MedChem Express
CAS-Nr.	155294-62-5
Menge	2 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 25 mg 2 mg 50 mg 5 mg
Kategorie	Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.48
Citations	Cell Death Dis. 2021 May 13;12(5):482. Cell Rep. 2020 Aug 4;32(5):107944. Nat Chem Biol. 2016 Jul;12(7):497-503. University of Toronto. Department of Medical Biophysics Adv Sci (Weinh). 2023 Sep;10(27):e2206878. Antioxidants (Basel). 2024 Jun 13;13(6):722. Cancer Res. 2022 Sep 2;82(17):3032-3044. Cell Chem Biol. 2021 Feb 16;S2451-9456(21)00051-9. Cell Metab. 2020 Apr 7;31(4):862-877.e14. Genome Biol. 2016 Jun 29;17(1):140. J Steroid Biochem Mol Biol. 2015 Aug;152:34-44. Sci China Life Sci. 2021 May 27;1-21. [1]Xia F, et al. Inhibition of cholesterol biosynthesis impairs secretion and voltage-gated calcium channel function in pancreatic beta-cells. Endocrinology. 2008 Oct;149(10):5136-45. [2]Horie M, et al. Effects of NB-598, a potent squalene epoxidase inhibitor, on the apical membrane uptake of cholesterol and basolateral membrane secretion of lipids in Caco-2 cells. Biochem Pharmacol. 1993 Jul 20;46(2):297-305. [3]Horie M, et al. An inhibitor of squalene epoxidase, NB-598, suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. Biochim Biophys Acta. 1993 May 20;1168(1):45-51.
Smiles	O=C(O)/C=C\C(O)=O.CC(C)(C)C#C/C=C/CN(CC)CC1=CC(OCC2=CC(C3=CSC=C3)=CS2)=CC=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Metabolism-sugar/lipid metabolism
Manufacturer - Targets	Others
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, stored under nitrogen)
Product Description	NB-598 Maleate is a potent and competitive inhibitor of squalene epoxidase (SE), and suppresses triglyceride biosynthesis through the farnesol pathway. NB-598 (Maleate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Manufacturer - Research Area	Metabolic Disease
Solubility	DMSO : 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Others
Clinical information	No Development Reported

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HY-16343C-2mg-safety-datasheet.pdf