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Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free (MALS verified)

Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free (MALS verified)

ArtNr	IT6-M52W9-100ug
Hersteller	ACROBiosystems
Menge	100 ug
Quantity options	100 ug 1 mg
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Solid
Specific against	Mouse (Murine, Mus musculus)
Host	HEK293
Konjugat/Tag	Unconjugated, HIS
Purity	90%
NCBI	NP_002201.1 , NP_067334.1
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Integrin alpha V beta 6,ITGAV&ITGB6
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Category	Protein / Bio-Markers & CD Antigens
Manufacturer - Conjugate / Tag	C-10xHis \| Native, Unconjugated
Shipping Temperature	RT
Storage Conditions	-20°C
Molecular Weight	112.5 kDa (ITGAV) & 80.2 kDa (ITGB6)
Manufacturer - Format	Powder
Description	Mouse ITGAV&ITGB6 Heterodimer Protein, His Tag&Tag Free (IT6-M52W9) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Val 988 (ITGAV) & Gly 22 - Pro 708 (ITGB6) (Accession # P43406-1 (ITGAV) & Q9Z0T9-1 (ITGB6)).
Background	Integrin alpha V beta 6 is a heterodimer of beta-6 associating with alpha-V. Integrin alpha-V beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Also, Integrin alpha-V beta-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1. Furthermore, it binds the TGF-beta latency‑associated peptide (LAP) and activates TGF-beta 1 or TGF-beta 3 from large latent complexes. This activation requires interaction with LTBP-1 and fibronectin, and is enhanced by PAR-1.
Molecule	Integrin alpha V beta 6
Exp Region	Phe 31 - Val 988 (ITGAV) & Gly 22 - Pro 708 (ITGB6)
Characteristics	Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAV and ITGB6, has a calculated MW of 112.5 kDa (ITGAV) and 80.2 kDa (ITGB6). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB6 contains no tag but a basic tail at the C-terminus. The predicted N-terminus is Phe 31 (ITGAV) & Gly 22 (ITGB6). The non-reducing (NR) protein migrates as 135-145 kDa (ITGAV) & 80-90 kDa (ITGB6) respectively due to glycosylation.
Endotoxin	1.0 EU per μg
Buffer	50 mM Tris, 150 mM NaCl, pH7.5
Stability	● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant	trehalose

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

IT6-M52W9-100ug-datasheet.pdf

IT6-M52W9-100ug-safety-datasheet.pdf