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SARS-CoV-2 Spike S2 protein, His Tag (BA.2/Omicron)

SARS-CoV-2 Spike S2 protein, His Tag (BA.2/Omicron)

ArtNr	S2N-C52Hh-100ug
Hersteller	ACROBiosystems
Menge	100 ug
Kategorie	Peptides & Proteins Amino Acids
Typ	Proteins
Format	Powder
Specific against	SARS-CoV-2
Host	HEK293
Konjugat/Tag	Unconjugated, HIS
Purity	95%
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Spike,S2 protein,Spike glycoprotein Subunit2,S glycoprotein Subunit2,Spike protein S2
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Manufacturers Category	Protein / Viral Proteins
Description	SARS-CoV-2 Spike S2 protein, His Tag (BA.2/Omicron) (S2N-C52Hh) is expressed from human 293 cells (HEK293). It contains AA Ser 686 - Pro 1213 (Accession # QHD43416.1 (N764K, D796Y, Q954H, N969K, F817P, A892P, A899P, A942P, K986P, V987P)). The spike mutations are identified on the SARS-CoV-2 Omicron variant (Pango lineage: BA.2/3/4/5). Proline substitutions (F817P, A892P, A899P, A942P, K986P, V987P) are introduced to prevent the formation of aggregates in the course of protein production.
Molecule	Spike S2
Exp Region	Ser 686 - Pro 1213
Storage	-20℃
Shipping	RT
Stability	-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Molecular Weight	60.0 kDa
Characteristics	This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 60.0 kDa. The protein migrates as 70-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin	1.0 EU per μg
Buffer	PBS, pH7.4
Background	It's been reported that SARS-CoV-2 can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

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Menge: 100 ug

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Lieferung vsl. bis 16.08.2024

Express-Lieferung: 3 Tage sparen

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