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Human Siglec-7 / CD328 Protein, Fc (L117A, L118A) Tag, low Endotoxin (MALS verified)

Human Siglec-7 / CD328 Protein, Fc (L117A, L118A) Tag, low Endotoxin (MALS verified)

ArtNr	SI7-H5258-500ug
Hersteller	ACROBiosystems
Menge	500 ug
Quantity options	500 ug 50 ug
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Solid
Specific against	Human (Homo sapiens)
Host	HEK293
Konjugat/Tag	Unconjugated, Fc
Purity	95%
NCBI	NP_055200.1
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	CDw328,D-siglec,A79 membrane protein,p75,Adhesion inhibitory receptor molecule 1,AIRM-1
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Category	Protein / Bio-Markers & CD Antigens
Manufacturer - Conjugate / Tag	C-Fc(A2), Unconjugated
Shipping Temperature	RT
Storage Conditions	-20°C
Molecular Weight	63.3 kDa
Manufacturer - Format	Powder
Description	Human Siglec-7, Fc (L117A, L118A) Tag (SI7-H5258) is expressed from human 293 cells (HEK293). It contains AA Gln 19 - Leu 353 (Accession # Q9Y286-1).
Background	Siglec-7 is a member of the human CD33‐related Siglec receptor. The extracellular region of Siglec‐7 is characterized by an N‐terminal V‐set Ig domain that can bind sialic acid and two C2‐set Ig domains. The cytoplasmic tail of Siglec‐7 has one immune‐receptor tyrosine‐based inhibitory motif (ITIM) and one ITIM‐like motif. Siglec-7 is considered as a sialic acid-dependent immunoreceptor with inhibitory potential and expressed predominantly on human NK cells, monocytes and a small subset of CD8+ T cells.
Molecule	Siglec-7
Exp Region	Gln 19 - Leu 353
Characteristics	This protein carries a Fc (L117A, L118A) tag at the C-terminus. The protein has a calculated MW of 63.3 kDa. The protein migrates as 70-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. Mutations (L117A, L118A/EU number: L234A/L235A) in human immunoglobulin G1 (hIgG1) Fc diminish binding to FcγRI leading to a significant reduction in ADCC and CDC in comparison to wild type human IgG1.
Endotoxin	0.01 EU per μg
Buffer	25 mM MES, 150 mM NaCl, pH 5.5
Stability	● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant	trehalose

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

SI7-H5258-500ug-datasheet.pdf

SI7-H5258-500ug-safety-datasheet.pdf