Human Tau-441 / 2N4R (273-380) Protein, His Tag (MALS verified)

Protein

RT

13.7 kDa

Tau is a microtubule-associated protein, which encodes by the MAPT gene that located on chromosome 17q21. Tau Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies. Tau-441 is known as "2N4R, " "Isoform Tau-F, " "Tau-4" or "Tau 441", which consisting of 441 amino acid. Tau-441 is a potential therapeutic target for pathogenesis.

Tau

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 13.7 kDa. The protein migrates as 16 kDa under reducing (R) condition (SDS-PAGE).

50 mM Tris, 150 mM NaCl, pH7.5

trehalose