CD40

MONOCLONAL ANTIBODIES, ANTI-HUMAN LYMPHOCYTES

Lyophilized: store at 4C. After reconstitution, if not intended for use within a month, aliquot and store at -20C.

CD40 is part of the TNF-receptor superfamily. CD40 is a necessary mediator for vast range of immune and inflammatory responses together with T cell-dependent immunoglobulin class switching, memory B cell growth, and germinal center formation. The transcription factor AKNA regulates the expression of CD40 and its ligand, which is vital for homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40 and serves as a mediator of the signal transduction. The interaction of CD40 and its ligand is crucial for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is the receptor for TNFSF5/CD40L.

Activated Human B cells.

Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.

Staining antibody. For staining, use 10ul/1, 000, 000 cells.