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Recombinant Human Interleukin-19

Recombinant Human Interleukin-19

ArtNr	cyt-363-10ug
Hersteller	ProSpec
Menge	10ug
Kategorie	Neuroscience Neural Lineage Markers Metabolism Diabetes Glucose Homeostasis Neural Transcription Factors Peptides & Proteins Recombinant Proteins
Typ	Cytokines and Growth Factors
Specific against	Human (Homo sapiens)
ECLASS 10.1	42030690
ECLASS 11.0	42030690
UNSPSC	12352202
Similar products	IL 19
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Synonyms	Melanoma differentiation association like protein, MDA1, NG 1, ZMDA1, IL-10C, IL-19
Introduction	IL19 is a cytokine that belongs to the IL10 cytokine subfamily. IL-19 is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described.
Description	Interleukin-19 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 155 amino acids and having a molecular mass of 17913 Dalton. The IL-19 is purified by proprietary chromatographic techniques.
Source	Escherichia Coli.
Physical Appearance	Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation	Lyophilized from a concentrated (1mg/ml) solution in water containing 10mM sodium citrate pH-5.
Purity	Greater than 99.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Usage	ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Amino acid sequence	The sequence of the first five N-terminal amino acids was determined and was found to be Met-Leu-Arg-Arg-Cys.
Biological Activity	The activity is determined by it's ability to activate STAT following receptor-ligand interaction.
Storage	Lyophilized Interleukin-19 although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution IL19 should be stored at 4C between 2-7 days and for future use below -18C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

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cyt-363-10ug-safety-datasheet.pdf