Midkine, His

ArtNr	cyt-444-20ug
Hersteller	ProSpec
Menge	20 ug
Quantity options	1 mg 20 ug 5 ug
Kategorie	Food Safety Histamines Peptides & Proteins Recombinant Proteins
Typ	Cytokines and Growth Factors
Format	Lyophilized
Specific against	Human (Homo sapiens)
Konjugat/Tag	HIS
Purity	Greater than 95% as determined by SDS-PAGE.
Sequence	MKHHHHHHHM KKKDKVKKGG PGSECAEWAW GPCTPSSKDC GVGFREGTCG AQTQRIRCRV PCNWKKEFGA DCKYKFENWG ACDGGTGTKV RQGTLKKARY NAQCQETIRV TKPCTPKTKA KAKAKKGKGK D.
ECLASS 10.1	42030690
ECLASS 11.0	42030690
UNSPSC	12352202
Alias	Midkine,His,NEGF-2,Neurite Growth-Promoting Factor 2,MK,Neurite outgrowth-promoting protein,Midgestation and kidney protein,Amphiregulin-associated protein,ARAP,Neurite outgrowth-promoting factor 2,FLJ27379,Midkine,MK1,NEGF2
Similar products	Midkine
Lieferbar
Manufacturer - Category	CYTOKINES AND GROWTH FACTORS
Storage Conditions	Store lyophilized protein at -20C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4C for a limited period of time, it does not show any change after two weeks at 4C.
Description	Recombinant Human Midkine, His Tag
Formulation	Lyophilized from 0.5mg/ml in 0.05M phosphate buffer and 0.1M NaCl, pH 7.2.
Introduction	Midkine (MK) is the product of a retinoic acid responsive gene, MK, and is a member of a family of heparin binding factors. It contains 121 amino acid residues including 10 conserved cysteine residues, all of which appear to be disulphide linked. Midkine is expressed during embryogenesis, showing an expression pattern that suggests functions in neurogenesis, cell migration, secondary organogenetic induction, and mesoderm-epithelial interaction. The widespread downregulation of MK in the adult human is reverted in a number of cancers, in which polypeptides are able to act as both transforming growth factors and promoters of angiogenesis. Midkine (MK), induces chemotaxis of human neutrophils and was found to trigger mobilization of intracellular calcium of these cells. Midkine induces histamine release from rat peritoneal mast cells with a rapid response in a dose dependent manner. Midkine is also a potent stimulator of collagen and glycosaminoglycan synthesis.
Usage	ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Manufacturer - Format	Filtered White lyophilized (freeze-dried) powder.

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cyt-444-20ug-safety-datasheet.pdf