SERPINB5

ArtNr	pro-202-1mg
Hersteller	ProSpec
Menge	1 mg
Quantity options	1 mg 20 ug 5 ug
Kategorie	Food Safety Allergenes Peptides & Proteins Recombinant Proteins
Typ	Proteins
Format	Lyophilized
Specific against	Human (Homo sapiens)
Purity	Greater than 97.0% as determined by<BR>(a) Analysis by HPLC.<BR>(b) Analysis by SDS-PAGE.
Sequence	MDALQLANSA FAVDLFKQLC EKEPLGNVLF SPICLSTSLS LAQVGAKGDT ANEIGQVLHF ENVKDIPFGF QTVTSDVNKL SSFYSLKLIK RLYVDKSLNL STEFISSTKR PYAKELETVD FKDKLEETKG QINNSIKDLT DGHFENILAD NSVNDQTKIL VVNAAYFVGK WMKKFPESET KECPFRLNKT DTKPVQMMNM EATFCMGNID SINCKIIELP FQNKHLSMFI LL
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	SERPINB5,PI5,maspin,SERPINB5,serpin peptidase inhibitor clade B (ovalbumin) member 5,Serpin B5,Protease inhibitor 5
Similar products	SERPINB5
Lieferbar
Manufacturer - Category	RECOMBINANT & NATURAL PROTEINS
Storage Conditions	Lyophilized SERPINB5 although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution SERPINB5 should be stored at 4C between 2-7 days and for future use below -18C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles .
Description	Recombinant Human Serpin Peptidase Inhibitor, Clade B Member 5
Formulation	Lyophilized from a0.2um filtered concentrated solution in PBS, pH7.0.
Introduction	SERPINB5 (Maspin) is a tumor suppressor protein of the serine proteinase inhibitor family. Maspin plays a vital role in embryonic development through critical functions in cell adhesion. In addition, Maspin is present in normal breast and prostatic epithelial cells although down regulated in the particular carcinomas. SERPINB5 impedes the growth, invasion, and metastatic properties of mammary tumors as well as the invasive ability of pancreatic ductal adenocarcinoma cells. SERPINB5 being a breast tumor suppressor gene is a significant marker of the disease progression in breast neoplasms. Furthermore, high expression of maspin is linked to squamous cell carcinoma in non-small-cell lung cancer. Moreover, maspin expression has been directly linked with the biological aggressiveness of ovarian carcinoma. Maspin exhibits no serine protease inhibitory activity since it does not undergo the stressed to relaxed conformational transition typical of active serpins.
Usage	ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Manufacturer - Format	Sterile Filtered White lyophilized (freeze-dried) powder.

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pro-202-1mg-safety-datasheet.pdf