Rat TNF-alpha protein

The recombinant RatTNF-alpha consists of 156 amino acids and has a predicted molecular mass of 17.2 kDa.

>98% as determined by SDS-PAGE

Endotoxin: <0.1 EU per ug of the protein as determined by the LAL method.

Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Rat TNF-alpha protein using the buffer we provided not less than 100 ug/mL, which can then be further diluted to other aqueous solutions.

The product is shipped at ambient temperature.

Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. Two receptors, TNF-R1 (TNF receptor type 1; CD120a; p55/60) and TNF-R2 (TNF receptor type 2; CD120b; p75/80), bind to TNF-alpha. TNF-alpha protein is produced mainly by macrophages, and large amounts of this cytokine are released in response to lipopolysaccharide, other bacterial products, and Interleukin-1 (IL-1). TNF-alpha is involved in fighting against the tumorigenesis, thus, is regarded as a molecular insight in cancer treatment.

TNF; TNFA; TNFSF2; DIF ; Tumor Necrosis Factor ; Tumor Necrosis Factor Ligand Superfamily Member; Tumor Necrosis Factor (TNF Superfamily, Member 2) ; Tumor Necrosis Factor Ligand 1F ; Tumor Necrosis Factor-Alpha ; TNF Superfamily, Member 2 ; TNLG1F 3; TNF 5

TNF-alpha