SARS-CoV-2 Spike Protein

SARS-CoV-2/COVID-19 Spike Protein is a recombinant protein expressed in E. coli.

The SARS-CoV-2 Spike Protein (S protein) is a viral protein that allows the entry of SARS-CoV-2 into human cells. The protein forms trimers on the viral capsid and binds to human Angiotensin Converting Enzyme 2 (ACE2) located on the cell surface. The protein has a cleavage site between the S1 and S2 subunits that is targeted by the human enzyme Furin, and it may also cause the development of a syncytium (cell fusion). Antibodies to S protein can prevent viral entry as well as target the virus for further immune action.

Prior to lyophilization: 20 mM Tris, pH 8.0, containing 0.01% Sarcosyl, 5% Trehalose.

Calculated MW: 60.1 kDa
Observed MW (SDS-PAGE): 60 kDa

Virus

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Glycoprotein