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Cynomolgus ALK-1/ACVRL1 Protein (ALK-CM101)

Cynomolgus ALK-1/ACVRL1 Protein (ALK-CM101)

ArtNr	ALK-CM101-100UG
Hersteller	KactusBio
Menge	100 ug
Quantity options	100 ug 500 ug
Kategorie	Oncology Neuroscience Molecular Targets for Neuroscience By Cell Type Blastoma Carcinoma Hematology Leukemia Lymphoma Myeloma Melanoma Peptides & Proteins Recombinant Proteins Astrocytoma Adenocarcinom
Typ	Proteins Recombinant
Format	Lyophilized
Specific against	Monkey (Cynomolgus, Simian)
Host	HEK293
Konjugat/Tag	HIS
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Sequence	Asp22-Gln118
NCBI	XP_005570958.1
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	ACVRLK1,ORW2,ALK1,ALK-1,EC 2.7.11,HHT,HHT2,SKR3,TSR-I,ACVRL1
Versandbedingung	Raumtemperatur
Lieferbar
Specificity	Cynomolgus
Manufacturer - Type	Recombinant Protein
Manufacturer - Targets	ALK-1/ACVRL1
Manufacturer - Conjugate / Tag	C-His
Shipping Temperature	Shipped at ambient temperature.
Storage Conditions	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Molecular Weight	The protein has a predicted MW of 11.86 kDa. Due to glycosylation, the protein migrates to 25-35 kDa based on Bis-Tris PAGE result.
Description	Recombinant Cynomolgus ALK-1/ACVRL1 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Asp22-Gln118.
Background	Activin receptor-like kinase 1 (ALK1)-mediated endothelial cell signalling in response to bone morphogenetic protein 9 (BMP9) and BMP10 is of significant importance in cardiovascular disease and cancer. Structural analyses reveal a tripartite recognition mechanism that defines BMP9 and BMP10 specificity for ALK1, and predict that crossveinless 2 is not an inhibitor of BMP9, which is confirmed by experimental evidence.
Endotoxin	Less than 1 EU per μg by the LAL method.
Formulation	Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 μg or less, at 1mg/ml for 500μg or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Biotinylated	no

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

ALK-CM101-100UG-datasheet.pdf

ALK-CM101-100UG-safety-datasheet.pdf