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Human ASGR1 / ASGPR1 Protein, Fc Tag (MALS verified)

Human ASGR1 / ASGPR1 Protein, Fc Tag (MALS verified)

ArtNr	AS1-H5253-1mg
Hersteller	ACROBiosystems
Menge	1 mg
Quantity options	100 ug 1 mg
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Solid
Specific against	Human (Homo sapiens)
Host	HEK293
Konjugat/Tag	Unconjugated, Fc
Purity	90%
Citations	(1) Bon C. et al., MAbs. 2017 Nov; 9(8): 1360-1369. (2) Tanowitz M. et al., Nucleic Acids Res. 2017 Dec 1; 45(21): 12388-12400. (3) Shi B. et al., J Histochem Cytochem. 2013 Dec; 61(12): 901-909.
NCBI	NP_001662.1
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	ASGP-R 1,ASGPR 1,C-type lectin domain family 4 member H1,Hepatic lectin H1,HL-1
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Category	Protein
Manufacturer - Conjugate / Tag	N-Fc, Unconjugated
Shipping Temperature	RT
Storage Conditions	-20°C
Molecular Weight	52.8 kDa
Manufacturer - Format	Powder
Description	ASGPR, a transmembrane C-type lectin, recognizes a wide variety of ligands that contain either terminal galactose (Gal) or N-acetylgalactosamine (GalNAc) residues and has been identified as a highly selective receptor on hepatocytes. The ASGR is composed of both a major (ASGR1) and minor subunit (ASGR2). ASGR1 has been shown to be efficiently targeted to the plasma membrane and to undergo constitutive endocytosis and recycling and found mainly expressed in the human liver.
Background	ASGPR, a transmembrane C-type lectin, recognizes a wide variety of ligands that contain either terminal galactose (Gal) or N-acetylgalactosamine (GalNAc) residues and has been identified as a highly selective receptor on hepatocytes. The ASGR is composed of both a major (ASGR1) and minor subunit (ASGR2). ASGR1 has been shown to be efficiently targeted to the plasma membrane and to undergo constitutive endocytosis and recycling and found mainly expressed in the human liver.
Molecule	ASGR1
Exp Region	Gln 62 - Leu 291
Characteristics	This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 52.8 kDa. The protein migrates as 65-75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin	1.0 EU per μg
Buffer	PBS, pH7.4
Stability	● -20°C to -70°C for 12 months in lyophilized state ● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant	trehalose

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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AS1-H5253-1mg-datasheet.pdf

AS1-H5253-1mg-safety-datasheet.pdf