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Cynomolgus B7-H6 / NCR3LG1 Protein, His Tag

Cynomolgus B7-H6 / NCR3LG1 Protein, His Tag

ArtNr	B76-C52Ha-100ug
Hersteller	ACROBiosystems
Menge	100 ug
Quantity options	100 ug 1 mg
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Solid
Specific against	Monkey (Cynomolgus, Simian)
Host	HEK293
Konjugat/Tag	Unconjugated
Purity	95%
Citations	(1) Wu MR, et all., 2015, Gene Ther. 22(8):675-84. (2) Phillips M, et all., 2016, Biopolymers. 106(5):658-72. (3) Flajnik MF, et all., 2012 Immunogenetics. 64(8):571-90.
NCBI	XP_005578557.1
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	B7-H6,NCR3LG1,B7 Homolog 6
Versandbedingung	Raumtemperatur
Lieferbar
Specificity	Cynomolgus
Manufacturer - Category	Protein
Manufacturer - Conjugate / Tag	C-10xHis, Unconjugated
Shipping Temperature	RT
Storage Conditions	-20°C
Molecular Weight	28.4 kDa
Manufacturer - Format	Powder
Description	The B7 family of genes is essential in the regulation of the adaptive immune system. one of which is the recently discovered B7H6. Humans and rats have a single B7H6 gene; however, many B7H6 genes were detected in a single large cluster in the Xenopus genome. Chimeric antigen receptor (CAR) T-cell therapies have demonstrated durable and potentially curative therapeutic efficacy against B-cell leukemia in clinical trials. In this study, B7H6, a ligand for the NK cell activating receptor NKp30, was targeted to create a CAR that targets multiple tumor types. B7H6 is expressed on various primary human tumors, including leukemia, lymphoma and gastrointestinal stromal tumors, but it is not constitutively expressed on normal tissues.
Background	The B7 family of genes is essential in the regulation of the adaptive immune system. one of which is the recently discovered B7H6. Humans and rats have a single B7H6 gene; however, many B7H6 genes were detected in a single large cluster in the Xenopus genome. Chimeric antigen receptor (CAR) T-cell therapies have demonstrated durable and potentially curative therapeutic efficacy against B-cell leukemia in clinical trials. In this study, B7H6, a ligand for the NK cell activating receptor NKp30, was targeted to create a CAR that targets multiple tumor types. B7H6 is expressed on various primary human tumors, including leukemia, lymphoma and gastrointestinal stromal tumors, but it is not constitutively expressed on normal tissues.
Molecule	B7-H6
Exp Region	Asp 25 - Asp 259
Characteristics	This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 28.4 kDa. The protein migrates as 38-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin	1.0 EU per μg
Buffer	PBS, pH7.4
Stability	● -20°C to -70°C for 12 months in lyophilized state ● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant	trehalose

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B76-C52Ha-100ug-datasheet.pdf

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