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Human CD30 / TNFRSF8 Protein, Fc Tag (MALS verified)

Human CD30 / TNFRSF8 Protein, Fc Tag (MALS verified)

ArtNr	CD0-H5250-100ug
Hersteller	ACROBiosystems
Menge	100 ug
Quantity options	100 ug 500 ug x 2
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Solid
Specific against	Human (Homo sapiens)
Host	HEK293
Konjugat/Tag	Unconjugated, Fc
Purity	95%
Citations	(1) Gorczyca W., et al., 2003, Int. J. Oncol. 22 (2): 319-24. (2) Aizawa S., et al., 1997, J. Biol. Chem. 272 (4): 2042-5. (3) Ansieau S., 1996, Proc. Natl. Acad. Sci. U.S.A. 93 (24): 14053-8. (4) Lee S.Y., et al., 1996, J. Exp. Med. 183:669-674.
NCBI	NP_001234.2
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	TNFRSF8,CD30,D1S166E,Ki-1
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Category	Protein
Manufacturer - Conjugate / Tag	C-Fc, Unconjugated
Shipping Temperature	RT
Storage Conditions	-20°C
Molecular Weight	64.62 kDa
Manufacturer - Format	Powder
Description	Human CD30 is also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. TNFRSF-8 is expressed by activated, but not by resting, T and B cells. Also, CD30 is expressed on classical Hodgkin Lymphoma cells together with CD15. CD30 is the receptor for TNFSF8/CD30L. CD30 can interact with TRAF2 and TRAF5, and mediate the signal transduction that leads to the activation of NF-kappa-B. TNFRSF8 may play a role in the regulation of cellular growth and transformation of activated lymphoblasts. TNFRSF8 is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity.
Background	Human CD30 is also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. TNFRSF-8 is expressed by activated, but not by resting, T and B cells. Also, CD30 is expressed on classical Hodgkin Lymphoma cells together with CD15. CD30 is the receptor for TNFSF8/CD30L. CD30 can interact with TRAF2 and TRAF5, and mediate the signal transduction that leads to the activation of NF-kappa-B. TNFRSF8 may play a role in the regulation of cellular growth and transformation of activated lymphoblasts. TNFRSF8 is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity.
Molecule	CD30
Exp Region	Phe 19 - Lys 379
Characteristics	This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 64.62 kDa. The protein migrates as 80-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin	0.2 EU per μg
Buffer	50 mM Tris, 100 mM Glycine, pH7.5
Stability	● -20°C to -70°C for 12 months in lyophilized state ● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant	trehalose

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CD0-H5250-100ug-datasheet.pdf

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