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Human CD4 Protein, Fc Tag (MALS verified)

Human CD4 Protein, Fc Tag (MALS verified)

ArtNr	CD4-H5259-1mg
Hersteller	ACROBiosystems
Menge	250 ug x 4
Quantity options	250 ug x 4 200 ug
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Solid
Specific against	Human (Homo sapiens)
Host	HEK293
Konjugat/Tag	Unconjugated, Fc
Purity	95%
Citations	(1) Brady RL, et al., 1993, Science 260 (5110): 979-83. (2) Zeitlmann, L., et al., 2001, J. Biol. Chem. (United States) 276 (12): 9123-32. (3) Rudd CE, et al., 2010, J. Immunol. 185 (5): 2645-9. (4) Rudd CE, et al., 1988, Proc. Natl. Acad. Sci. U.S.A. 85 (14): 5190-4. (5) Gorska MM, et al., 2004, J. Exp. Med. 199 (3): 369-79.
NCBI	AAH25782
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	CD4,CD4mut,LEU3
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Category	Protein
Manufacturer - Conjugate / Tag	C-Fc, Unconjugated
Shipping Temperature	RT
Storage Conditions	-20°C
Molecular Weight	67.7 kDa
Manufacturer - Format	Powder
Description	T-cell surface glycoprotein CD4 is also known as T-cell surface antigen T4/Leu-3. CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. CD4 is accessory protein for MHC class-II antigen/T-cell receptor interaction. CD4 induces the aggregation of lipid rafts. CD4 is a primary receptor used by HIV-1 to gain entry into host T cells. HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors. Therefore, medical professionals refer to the CD4 count to decide when to begin treatment for HIV-infected patients.
Background	T-cell surface glycoprotein CD4 is also known as T-cell surface antigen T4/Leu-3. CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. CD4 is accessory protein for MHC class-II antigen/T-cell receptor interaction. CD4 induces the aggregation of lipid rafts. CD4 is a primary receptor used by HIV-1 to gain entry into host T cells. HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors. Therefore, medical professionals refer to the CD4 count to decide when to begin treatment for HIV-infected patients.
Molecule	CD4
Exp Region	Lys 26 - Pro 396
Characteristics	This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 67.7 kDa. The protein migrates as 70-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin	0.2 EU per μg
Buffer	Tris, Glycine and NaCl, pH7.5
Stability	● -20°C to -70°C for 12 months in lyophilized state ● -70°C for 12 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant	trehalose

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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CD4-H5259-1mg-datasheet.pdf

CD4-H5259-1mg-safety-datasheet.pdf