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Human / Cynomolgus / Rhesus macaque CD28 Protein, Mouse IgG2a Fc Tag (MALS verified) Europäischer Partner

ArtNr CD8-H52A5-100ug
Hersteller ACROBiosystems
Menge 100 ug
Quantity options 100 ug 500 ug x 2
Kategorie
Typ Proteins Recombinant
Format Solid
Specific against Human (Homo sapiens), Monkey (Cynomolgus, Simian), Rhesus macaque
Host HEK293
Isotype IgG2a
Konjugat/Tag Unconjugated, C-mFc
Purity 95%
Citations (1)Evans E.J., et al., 2005, Nat. Immunol. 6:271-279. (2) Mayya V., et al., 2009, Sci. Signal. 2:RA46-RA46. (3) Wollscheid B., et al., 2009, Nat. Biotechnol. 27:378-386.
NCBI NP_006130.1
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias CD28,Tp44
Versandbedingung Raumtemperatur
Lieferbar
Specificity Human / Cynomolgus / Rhesus macaque
Manufacturer - Category
Protein
Manufacturer - Conjugate / Tag
C-mFc(mIgG2a), Unconjugated
Shipping Temperature
RT
Storage Conditions
-20°C
Molecular Weight
42.0 kDa
Manufacturer - Format
Powder
Description
Human / Cynomolgus / Rhesus macaque CD28, Mouse IgG2a Fc Tag (CD8-H52A5) is expressed from human 293 cells (HEK293). It contains AA Asn 19 - Pro 152 (Accession # P10747-1). In the region Asn 19 - Pro 152, the AA sequence of Human, Cynomolgus and Rhesus macaque CD28 are homologus.
Background
T-cell-specific surface glycoprotein CD28 is also known as TP44, is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.
Molecule
CD28
Exp Region
Asn 19 - Pro 152
Characteristics
This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 42.0 kDa. The protein migrates as 50-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
0.1 EU per μg
Buffer
50 mM Tris, 100 mM Glycine, pH7.5
Stability
● -20°C to -70°C for 12 months in lyophilized state
● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant
trehalose

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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