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Biotinylated Human CD3 epsilon&CD3 delta Heterodimer Protein, Fc,His,Avitag™&Fc,Flag,Avitag™ (MALS verified)

Biotinylated Human CD3 epsilon&CD3 delta Heterodimer Protein, Fc,His,Avitag™&Fc,Flag,Avitag™ (MALS verified)

ArtNr	CDD-H82F6-200ug
Hersteller	ACROBiosystems
Menge	200 ug
Quantity options	200 ug 25 ug
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Solid
Specific against	Human (Homo sapiens)
Host	HEK293
Konjugat/Tag	Biotin, FLAG, Avi, Fc
Purity	90%
Citations	(1) Gold DP, et al., 1986, Nature 321 (6068): 431-4. (2) Clevers HC, et al., 1988, Proc. Natl. Acad. Sci. U.S.A. 85 (21): 8156-60. (3) Gil J, et al., 2011, J Clin Invest, 121(10):3872-6. (4) Lu X, et al.,2011, Hematology, 16(3):185-9.
NCBI	NP_000724.1 (CD3E), NP_000723.1 (CD3D)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	CD3E & CD3D,CD3 delta & CD3 epsilon,CD3 delta / epsilon
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Category	Protein
Manufacturer - Conjugate / Tag	C-Fc & C-10xHis & C-Avi \| C-Fc & C-Flag & C-Avi, Biotin-labeled
Shipping Temperature	RT
Storage Conditions	-20°C
Molecular Weight	45.1 kDa (CD3E) & 42.6 kDa (CD3D)
Manufacturer - Format	Powder
Description	MABSol® Biotinylated Human CD3E&CD3D Heterodimer Protein, Fc, His, Avitag&Fc, Flag, Avitag (CDD-H82F6) is expressed from human HEK293 cells. It contains AA Asp 23 - Asp 126 (CD3E) & Phe 22 - Ala 105 (CD3D) (Accession # P07766-1 (CD3E) & P04234-1 (CD3D)). It is the biotinylated form of Human CD3 epsilon & CD3 delta Protein.
Background	T-cell surface glycoprotein CD3 delta & CD3 epsilon chain, also known as CD3D & CD3E or CD3D&CD3E respectively, are single-pass type I membrane proteins. CD3D, together with CD3- epsilon(CD3E) , CD3-gamma and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.
Molecule	CD3E & CD3D
Exp Region	Asp 23 - Asp 126 (CD3E) & Phe 22 - Ala 105 (CD3D)
Characteristics	Biotinylated Human CD3E&CD3D Heterodimer Protein, Fc, His, Avitag&Fc, Flag, Avitag is produced by co-expression of CD3E and CD3D, has a calculated MW of 45.1 kDa (CD3E) & 42.6 kDa (CD3D). Subunit CD3E is fused with a human IgG1 Fc fragment at the C-terminus, followed by an Avi tag (Avitag™), the polyhistidine tag is inserted in-between the Fc and Avi tags at the C-terminus and subunit CD3D contains a human IgG1 Fc fragment at the C-terminus, followed by an Avi tag (Avitag™), the flag tag is inserted in-between the Fc and Avi tags at the C-terminus. As a result of glycosylation, the heterodimer protein migrates as 50-60 kDa under reducing (R) condition.
Endotoxin	1.0 EU per μg
Buffer	PBS, pH7.4
Stability	● -20°C to -70°C for 12 months in lyophilized state ● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant	trehalose

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

CDD-H82F6-200ug-datasheet.pdf

CDD-H82F6-200ug-safety-datasheet.pdf