Human B7-2 Protein, mFc-His Tag

B7-2

The protein has a predicted molecular mass of 52.4 kDa after removal of the signal peptide.

This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.

Recombinant human B7-2 protein with C-terminal mouse Fc and 6xHis tag

Research use only