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Rabbit FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Tag Free (MALS & SPR verified)

Rabbit FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Tag Free (MALS & SPR verified)

ArtNr	FCM-R52W5-1mg
Hersteller	ACROBiosystems
Menge	500 ug x 2
Quantity options	500 ug x 2 50 ug
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Solid
Specific against	Rabbit (Oryctolagus cuniculus)
Host	HEK293
Konjugat/Tag	Unconjugated
Purity	95%
Citations	(1) Goebl NA., et al., 2008, Mol. Biol. Cell 19 (12): 5490-505. (2) Lee TY., et al., 2008, Clin. Cancer Res. 14 (5): 1487-93. (3) Güssow D., et al., 1987, J. Immunol. 139 (9): 3132-8. (4) Gorevic P.D., et al., 1986, Proc. Natl. Acad. Sci. U.S.A. 83:7908-7912.
NCBI	ABY47597.1 (FCGRT), ALR85722.1 (B2M)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	FcRn,FCGRT & B2M
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Category	Protein
Manufacturer - Conjugate / Tag	C-10xHis \| Native, Unconjugated
Shipping Temperature	RT
Storage Conditions	-20°C
Molecular Weight	32.1 kDa (FCGRT) & 11.7 kDa (B2M)
Manufacturer - Format	Powder
Description	FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer. Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk. FCGRT possible role in transfer of immunoglobulin G from mother to fetus. Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system.
Background	FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer. Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk. FCGRT possible role in transfer of immunoglobulin G from mother to fetus. Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system.
Molecule	FcRn (FCGRT & B2M)
Exp Region	Ala 24 - Val 297 (FCGRT) & Val 22 - Tyr 120 (B2M)
Characteristics	Rabbit FCGRT&B2M Heterodimer Protein, His Tag&Tag Free, produced by co-expression of FCGRT and B2M, has a calculated MW of 32.1 kDa (FCGRT) and 11.7 kDa (B2M). Subunit FCGRT is fused with a polyhistidine tag at the C-terminus and subunit Beta-2 microglobulin (B2M) contains no tag at the C-terminus. The reducing (R) protein migrates as 34 kDa (FCGRT) and 12 kDa (B2M) respectively due to glycosylation.
Endotoxin	1.0 EU per μg
Buffer	PBS, pH7.4
Stability	● -20°C to -70°C for 12 months in lyophilized state ● -70°C for 12 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant	trehalose

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FCM-R52W5-1mg-datasheet.pdf

FCM-R52W5-1mg-safety-datasheet.pdf