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Human Osteoactivin / GPNMB Protein, His Tag

Human Osteoactivin / GPNMB Protein, His Tag

ArtNr	GPB-H5229-1mg
Hersteller	ACROBiosystems
Menge	500 ug x 2
Quantity options	100 ug 500 ug x 2
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Solid
Specific against	Human (Homo sapiens)
Host	HEK293
Konjugat/Tag	Unconjugated
Purity	95%
Citations	(1) Weterman MA., et al., 1995, International Journal of Cancer 60 (1): 73-81. (2) Abdelmagid, SM., et al., 2008, Exp Cell Res 314 (13): 2334-51. (3) Abdelmagid SM., et al., 2007, J Cell Physiol. 210 (1): 26-37.
NCBI	AAH32783
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	GPNMB,HGFIN,NMB,Osteoactivin
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Category	Protein
Manufacturer - Conjugate / Tag	C-10xHis, Unconjugated
Shipping Temperature	RT
Storage Conditions	-20°C
Molecular Weight	53.4 kDa
Manufacturer - Format	Powder
Description	Transmembrane glycoprotein NMB (GPNMB) is also known as Transmembrane glycoprotein HGFIN, DC-HIL and Osteoactivin (OA), which belongs to the PMEL/NMB family. GPNMB contains one PKD domain. GPNMB is a transmembrane glycoprotein that is up-regulated in various cancer cells, including in glioblastoma multiforme and is expressed in many melanoma cells, as well as in tissue macrophages. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages.
Background	Transmembrane glycoprotein NMB (GPNMB) is also known as Transmembrane glycoprotein HGFIN, DC-HIL and Osteoactivin (OA), which belongs to the PMEL/NMB family. GPNMB contains one PKD domain. GPNMB is a transmembrane glycoprotein that is up-regulated in various cancer cells, including in glioblastoma multiforme and is expressed in many melanoma cells, as well as in tissue macrophages. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages.
Molecule	Osteoactivin
Exp Region	Ala 22 - Pro 486
Characteristics	This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 53.4 kDa. The protein migrates as 85-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin	1.0 EU per μg
Buffer	PBS, pH7.4
Stability	● -20°C to -70°C for 12 months in lyophilized state ● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant	trehalose

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GPB-H5229-1mg-datasheet.pdf

GPB-H5229-1mg-safety-datasheet.pdf