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Animal-Free GDF-11/BMP-11, Human (His)

Animal-Free GDF-11/BMP-11, Human (His)

ArtNr	HY-P700020AF-2ug
Hersteller	MedChem Express
Menge	2 ug
Quantity options	10 ug 1 ea 2 ug 50 ug
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Specific against	other
Purity	98.0
Sequence	MNLGLDCDEH SSESRCCRYP LTVDFEAFGW DWIIAPKRYK ANYCSGQCEY MFMQKYPHTH LVQQANPRGS AGPCCTPTKM SPINMLYFND KQQIIYGKIP GMVVDRCGCS
Citations	[1]Walker RG, et al. Structural basis for potency differences between GDF8 and GDF11. BMC Biol. 2017 Mar 3;15(1):19. [2]Schafer MJ, et al. The influence of GDF11 on brain fate and function. Geroscience. 2019 Feb;41(1):1-11. [3]Cox TC, et al. Mutations in GDF11 and the extracellular antagonist, Follistatin, as a likely cause of Mendelian forms of orofacial clefting in humans. Hum Mutat. 2019 Oct;40(10):1813-1825. [4]Hannan NR, et al. BMP-11 and myostatin support undifferentiated growth of human embryonic stem cells in feeder-free cultures. Cloning Stem Cells. 2009 Sep;11(3):427-35. [5]Pham HG, et al. BMP11 regulates thermogenesis in white and brown adipocytes. Cell Biochem Funct. 2021 Jun;39(4):496-510.
Smiles	MNLGLDCDEH SSESRCCRYP LTVDFEAFGW DWIIAPKRYK ANYCSGQCEY MFMQKYPHTH LVQQANPRGS AGPCCTPTKM SPINMLYFND KQQIIYGKIP GMVVDRCGCS
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Animal-Free GDF-11/BMP-11 Protein, Human (His),Human,E. coli
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Recombinant Proteins
Shipping Temperature	Blue Ice
Storage Conditions	Stored at -20°C for 2 years
Molecular Weight	Approximately 13.40 kDa
Product Description	Bone morphogenetic protein 11 (BMP-11; GDF11), also known as growth/differentiation factor 11, is a polymorphic ligand protein belonging to the TGFβ family. The GDF-11/BMP-11 signal activates the signal through activator receptor types I and II, resulting in the phosphorylation of SMAD2 and SMAD3[1]. GDF-11/BMP-11 is an important regulator of central nervous system (CNS) formation and fate[2]. Exogenous peripheral delivery of GDF-11/BMP-11 may enhance neurogenesis and angiogenesis and improve neuropathological outcomes in the elderly brain[2]. The total length of human GDF-11/BMP-11 protein is 407 amino acids (M1-M407), with a glycosylation domain. Animal-Free GDF-11/BMP-11 Protein, Human (His) has a total length of 109 amino acids (N299-S407), is expressed in E. coli with C-terminal His-tag.This product is for cell culture use only.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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